HECA

Across TCGA patient cohorts, HECA mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECA-associated genes across cancer lineages are eIF4E, PDCD4, and PKC-b-II_pS660. Each is linked with HECA in more than 1 cancer types. Because this analysis shows association rather than direction, both HECA-to-partner and partner-to-HECA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HECA-low versus HECA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECA→partner) and Y-score (partner→HECA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.164	+2.235	.011	.005	3	2
UCEC	PDCD4 →	-0.425	-2.321	.003	.005	3	2
UCEC	PKC-b-II_pS660 →	-0.181	-1.064	.032	.048	3	2
UCEC	Bax →	+0.159	+1.087	.030	.048	3	2
UCEC	Caspase-7-cleavedD198 →	+0.911	+2.736	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.352	+1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by HECA expression — UCEC

Explore this box plot interactively →