HECA

Across TCGA cell cohorts, HECA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,507 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HECA-associated GO terms across cancer lineages are Positive regulation of cytoplasmic translation, Regulation of autophagosome assembly, and Small GTPase-mediated signal transduction. Each is linked with HECA in more than 10 cancer types. Because this analysis shows association rather than direction, both HECA-to-partner and partner-to-HECA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic translation grouped by HECA-low versus HECA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HECA→partner) and Y-score (partner→HECA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of cytoplasmic translation →	+0.152	+1.065	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of autophagosome assembly →	+0.072	+1.001	.002	<.001	3	11
PANCREAS	Small GTPase-mediated signal transduction →	+0.065	+0.867	<.001	<.001	3	10
OESOPHAGUS	Regulation of cytoplasmic mRNA processing body assembly →	+0.137	+0.767	<.001	.002	2	11
URINARY_TRACT	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.085	+0.735	.001	.003	3	10
KIDNEY	Negative regulation of macroautophagy →	+0.069	+0.766	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,507 associations by consensus.

Positive regulation of cytoplasmic translation by HECA expression — LUNG_SCLC

Explore this box plot interactively →