HECA

Across TCGA cell cohorts, HECA mutation is significantly associated with the RNA expression of many other genes, with 933 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECA-associated genes across cancer lineages are C8B, PES1, and ANKRD54. Each is linked with HECA in more than 1 cancer types. Because this analysis shows association rather than direction, both HECA-to-partner and partner-to-HECA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8B grouped by HECA-low versus HECA-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECA→partner) and Y-score (partner→HECA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C8B →	+0.010	+4.781	<.001	.003	3	1
LARGE_INTESTINE	PES1 →	+0.479	+2.675	.006	.003	3	1
LARGE_INTESTINE	ANKRD54 →	+0.576	+3.714	<.001	<.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.564	+3.321	.002	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.721	+3.330	<.001	.002	3	1
LARGE_INTESTINE	POLDIP3 →	+0.574	+3.362	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 933 associations by consensus.

C8B by HECA expression — BREAST

Explore this box plot interactively →