HEATR9

Across TCGA patient cohorts, HEATR9 mutation is significantly associated with the RNA expression of many other genes, with 3,182 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR9-associated genes across cancer lineages are EIF2B1, MAPKAPK3, and RNA5SP99. Each is linked with HEATR9 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR9-to-partner and partner-to-HEATR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B1 grouped by HEATR9-low versus HEATR9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR9→partner) and Y-score (partner→HEATR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B1 →	+0.359	+3.086	<.001	<.001	3	3
UCEC	MAPKAPK3 →	+0.325	+2.447	.009	.001	3	3
HNSC	RNA5SP99 →	+0.237	+4.505	<.001	.009	3	3
SKCM	DDX20 →	+0.598	+3.826	.002	<.001	3	3
SKCM	RAD18 →	+0.677	+2.719	.002	.003	3	3
UCEC	RFT1 →	+0.352	+2.415	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,182 associations by consensus.

EIF2B1 by HEATR9 expression — UCEC

Explore this box plot interactively →