HEATR6

Across TCGA pan-cancer cohorts, HEATR6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HEATR6 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HEATR6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HEATR6 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where HEATR6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.123	0.785	.009	25	view →
PDAC	OS	Quartile	II,III,IV	0.406	0.616	.010	11	view →
LSCC	DFS	Tertile	All	0.196	0.823	.002	10	view →
HNSC	DFS	Quartile	IV	0.553	0.864	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HEATR6–CCRCC (OS)

Open the CCRCC breakdown →