HEATR5B

Across TCGA pan-cancer cohorts, HEATR5B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HEATR5B data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HEATR5B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HEATR5B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where HEATR5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	1.000	0.600	.008	27	view →
PDAC	DFS	Quartile	II,III,IV	0.582	0.233	.003	16	view →
LUAD	OS	Median	II,III,IV	1.000	0.818	.014	11	view →
HNSC	OS	Quartile	II,III,IV	0.853	0.554	.009	6	view →
LSCC	DFS	Quartile	All	1.000	0.855	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HEATR5B–CCRCC (DFS)

Open the CCRCC breakdown →