HEATR5B

Across TCGA patient cohorts, HEATR5B mutation is significantly associated with the RNA expression of many other genes, with 4,235 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR5B-associated genes across cancer lineages are SEC13, CENPM, and NDUFA6. Each is linked with HEATR5B in more than 4 cancer types. Because this analysis shows association rather than direction, both HEATR5B-to-partner and partner-to-HEATR5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by HEATR5B-low versus HEATR5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR5B→partner) and Y-score (partner→HEATR5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.293	+1.469	<.001	<.001	3	5
COAD	CENPM →	+0.919	+2.710	<.001	.003	3	5
COAD	NDUFA6 →	+0.579	+3.223	<.001	.008	3	5
UCEC	C19orf47 →	+0.282	+1.501	.001	<.001	3	4
UCEC	TXLNB →	-0.300	-1.963	<.001	<.001	3	4
UCEC	ZBTB8OS →	+0.270	+1.501	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,235 associations by consensus.

SEC13 by HEATR5B expression — UCEC

Explore this box plot interactively →