HEATR5B

Across TCGA patient cohorts, HEATR5B mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR5B-associated genes across cancer lineages are ASNS, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with HEATR5B in more than 5 cancer types. Because this analysis shows association rather than direction, both HEATR5B-to-partner and partner-to-HEATR5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HEATR5B-low versus HEATR5B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR5B→partner) and Y-score (partner→HEATR5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.726	+3.321	<.001	.009	3	6
UCEC	Cyclin-B1 →	+0.649	+1.830	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+1.350	+3.186	<.001	.009	3	5
UCEC	STAT3_pY705 →	-0.371	-1.632	<.001	<.001	3	4
UCEC	ATM →	-0.481	-1.986	<.001	.002	3	4
COAD	Cyclin-E1 →	+0.264	+3.169	.009	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

ASNS by HEATR5B expression — COAD

Explore this box plot interactively →