HEATR5B

Across TCGA cell cohorts, HEATR5B mutation is significantly associated with the RNA expression of many other genes, with 730 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEATR5B-associated genes across cancer lineages are CDR2, TADA2B, and SIKE1. Each is linked with HEATR5B in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR5B-to-partner and partner-to-HEATR5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDR2 grouped by HEATR5B-low versus HEATR5B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR5B→partner) and Y-score (partner→HEATR5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDR2 →	+0.641	+2.743	<.001	.001	3	3
BLOOD_Leukemia	TADA2B →	+0.474	+3.366	.003	.002	3	3
LARGE_INTESTINE	SIKE1 →	+0.498	+3.386	.008	.001	3	3
BLOOD_Myeloma	G6PC →	+0.017	+3.906	.009	.009	3	2
OESOPHAGUS	GIMAP8 →	+0.028	+3.321	.002	.005	3	2
LUNG_SCLC	PRAMEF33 →	+0.392	+4.614	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 730 associations by consensus.

CDR2 by HEATR5B expression — LARGE_INTESTINE

Explore this box plot interactively →