Across TCGA patient cohorts, HEATR4 mutation is significantly associated with the RNA expression of many other genes, with 3,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR4-associated genes across cancer lineages are DBF4B, TIMM22, and GTSE1. Each is linked with HEATR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR4-to-partner and partner-to-HEATR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR4→partner) and Y-score (partner→HEATR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DBF4B →	+0.519	+3.729	<.001	<.001	3	3
COAD	TIMM22 →	+0.590	+3.335	<.001	.005	3	3
UCEC	GTSE1 →	+0.694	+1.922	<.001	<.001	3	3
STAD	MIR6821 →	+0.288	+4.641	<.001	.005	3	3
UCEC	CCDC137 →	+0.412	+1.890	<.001	<.001	3	3
UCEC	KIF18B →	+0.686	+2.120	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,185 associations by consensus.

Exploration

HEATR4 survival (RNA) · tumor vs normal (RNA) · all HEATR4 data types