HEATR4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HEATR4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR4-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Lck. Each is linked with HEATR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR4-to-partner and partner-to-HEATR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR4→partner) and Y-score (partner→HEATR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+0.639+2.019<.001.00133
UCECMEK1 →+0.350+2.736.001<.00132
COADLck →+0.644+2.832<.001.03532
UCECEGFR_pY1068 →-0.243-1.947.001<.00132
UCECPDCD4 →-0.557-2.127<.001<.00132
UCEC4E-BP1 →+0.291+3.807<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration