Across TCGA cell cohorts, HEATR4 mutation is significantly associated with the RNA expression of many other genes, with 810 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEATR4-associated genes across cancer lineages are OR2T29, OR2M7, and OR2T2. Each is linked with HEATR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEATR4-to-partner and partner-to-HEATR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR4→partner) and Y-score (partner→HEATR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR2T29 →	+0.116	+4.906	<.001	.006	3	1
LUNG_SCLC	OR2M7 →	+0.040	+5.643	<.001	.002	3	1
LUNG_SCLC	OR2T2 →	+0.023	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF11 →	+0.026	+5.029	<.001	.006	3	1
BLOOD_Leukemia	DEFB126 →	+0.046	+5.969	<.001	.001	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.109	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 810 associations by consensus.

Exploration

HEATR4 survival (RNA) · tumor vs normal (RNA) · all HEATR4 data types