HEATR3

Across TCGA patient cohorts, HEATR3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,848 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HEATR3-associated genes across cancer lineages are SHCBP1, CENPN, and ORC6. Each is linked with HEATR3 in more than 7 cancer types. Because this analysis shows association rather than direction, both HEATR3-to-partner and partner-to-HEATR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HEATR3 versus SHCBP1 in BRCA, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR3→partner) and Y-score (partner→HEATR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SHCBP1 →	+0.772	+0.356	<.001	<.001	3	8
OV	CENPN →	+0.723	+0.367	<.001	<.001	3	7
BRCA	ORC6 →	+0.979	+0.307	<.001	<.001	3	7
LUAD	HMMR →	+1.058	+0.345	<.001	<.001	3	7
BRCA	DLGAP5 →	+1.068	+0.328	<.001	<.001	3	6
HNSC	NIP7 →	+0.792	+0.335	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,848 associations by consensus.

HEATR3 vs SHCBP1 — BRCA

Explore this scatter interactively →