HEATR3

Across TCGA cell cohorts, HEATR3 mutation is significantly associated with the mutation status of many other genes, with 3,533 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEATR3-associated genes across cancer lineages are DIP2A, FGGY, and FBXO7. Each is linked with HEATR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR3-to-partner and partner-to-HEATR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIP2A grouped by HEATR3-low versus HEATR3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR3→partner) and Y-score (partner→HEATR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DIP2A →	+4.502	+5.066	.007	.007	1	3
UPPER_AERODIGESTIVE_TRACT	FGGY →	+4.392	+4.954	.008	.008	1	3
LARGE_INTESTINE	FBXO7 →	+2.407	+2.886	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	PDE8B →	+5.392	+5.392	.004	.004	1	3
LARGE_INTESTINE	KMT2A →	+2.077	+3.129	.004	.004	1	3
LARGE_INTESTINE	OLFM3 →	+3.799	+3.329	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,533 associations by consensus.

DIP2A by HEATR3 expression — LUNG_SCLC

Explore this box plot interactively →