HEATR3

Across TCGA cell cohorts, HEATR3 mutation is significantly associated with the drug of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEATR3-associated genes across cancer lineages are Niraparib, GSK2801, and KRAS (G12C) Inhibitor-12. Each is linked with HEATR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEATR3-to-partner and partner-to-HEATR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by HEATR3-low versus HEATR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR3→partner) and Y-score (partner→HEATR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.375	+2.646	.035	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.323	+2.649	.043	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.620	+2.646	.012	.047	3	1
LARGE_INTESTINE	CDK9_5038 →	+0.621	+2.906	.024	.033	1	1
LARGE_INTESTINE	JAK1_8709 →	+0.433	+2.649	.028	.046	1	1
LARGE_INTESTINE	LMB_AB1 →	+0.306	+2.649	.041	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Niraparib by HEATR3 expression — LARGE_INTESTINE

Explore this box plot interactively →