HEATR1

Across TCGA pan-cancer cohorts, HEATR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HEATR1 data layer compared with 25 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HEATR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HEATR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where HEATR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.373	0.771	<.001	97	view →
PDAC	DFS	Median	II,III,IV	0.297	0.531	.005	15	view →
LUAD	DFS	Median	III,IV	0.713	0.286	.026	12	view →
LSCC	DFS	Tertile	II,III,IV	0.896	0.530	.011	11	view →
HNSC	OS	Median	All	0.789	0.904	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HEATR1–CCRCC (DFS)

Open the CCRCC breakdown →