HEATR1

Across TCGA cell cohorts, HEATR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,190 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HEATR1-associated GO terms across cancer lineages are Transcription by RNA polymerase I, Protein localization to nucleolus, and Positive regulation of rRNA processing. Each is linked with HEATR1 in more than 19 cancer types. Because this analysis shows association rather than direction, both HEATR1-to-partner and partner-to-HEATR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription by RNA polymerase I grouped by HEATR1-low versus HEATR1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR1→partner) and Y-score (partner→HEATR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase I →	+0.113	+1.151	<.001	<.001	3	20
BONE	Protein localization to nucleolus →	+0.182	+1.283	<.001	<.001	3	19
BLOOD_Lymphoma	Positive regulation of rRNA processing →	+0.142	+0.962	<.001	<.001	3	19
LUNG_SCLC	Maturation of SSU-rRNA →	+0.136	+0.921	<.001	<.001	3	19
OVARY	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.112	+0.784	<.001	<.001	3	19
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.129	+1.003	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,190 associations by consensus.

Transcription by RNA polymerase I by HEATR1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →