HEATR1

Across TCGA cell cohorts, HEATR1 mutation is significantly associated with the RNA expression of many other genes, with 358 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEATR1-associated genes across cancer lineages are CXorf51A, KRTAP17-1, and CCL8. Each is linked with HEATR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR1-to-partner and partner-to-HEATR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXorf51A grouped by HEATR1-low versus HEATR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR1→partner) and Y-score (partner→HEATR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CXorf51A →	+0.362	+3.510	<.001	.003	3	3
LUNG_NSCLC_LUAD	KRTAP17-1 →	+0.013	+2.813	<.001	.007	3	2
BLOOD_Lymphoma	CCL8 →	+0.015	+3.584	<.001	.004	3	2
LUNG_NSCLC_LUSC	WFDC11 →	+0.053	+4.643	<.001	.008	3	1
LIVER	CCDC178 →	+0.085	+3.977	.006	.006	3	1
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 358 associations by consensus.

CXorf51A by HEATR1 expression — SKIN

Explore this box plot interactively →