HDLBP

Across TCGA pan-cancer cohorts, HDLBP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HDLBP data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HDLBP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDLBP expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where HDLBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.473	0.861	<.001	45	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	22	view →
LSCC	DFS	Quartile	II,III,IV	0.586	0.956	.003	19	view →
GBM	DFS	Quartile	All	0.216	0.521	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HDLBP–CCRCC (DFS)

Open the CCRCC breakdown →