HDLBP

Across TCGA cell cohorts, HDLBP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,269 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HDLBP-associated GO terms across cancer lineages are Regulation of modification of synaptic structure, Endosomal transport, and Retrograde transport, endosome to Golgi. Each is linked with HDLBP in more than 12 cancer types. Because this analysis shows association rather than direction, both HDLBP-to-partner and partner-to-HDLBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of modification of synaptic structure grouped by HDLBP-low versus HDLBP-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDLBP→partner) and Y-score (partner→HDLBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of modification of synaptic structure →	+0.135	+0.878	<.001	<.001	3	13
BONE	Endosomal transport →	+0.084	+0.998	<.001	<.001	3	12
LARGE_INTESTINE	Retrograde transport, endosome to Golgi →	+0.074	+0.972	<.001	<.001	3	12
LARGE_INTESTINE	Cytosolic transport →	+0.067	+0.737	<.001	<.001	3	11
SKIN	Otolith mineralization →	+0.116	+0.655	<.001	<.001	3	11
PANCREAS	Endocytic recycling →	+0.051	+0.488	.002	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,269 associations by consensus.

Regulation of modification of synaptic structure by HDLBP expression — LARGE_INTESTINE

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