HDLBP

Across TCGA cell cohorts, HDLBP mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDLBP-associated genes across cancer lineages are IAP_5620, Fulvestrant, and PLX-4720. Each is linked with HDLBP in more than 1 cancer types. Because this analysis shows association rather than direction, both HDLBP-to-partner and partner-to-HDLBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IAP_5620 grouped by HDLBP-low versus HDLBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDLBP→partner) and Y-score (partner→HDLBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IAP_5620 →	+0.444	+2.649	.015	.046	3	1
LARGE_INTESTINE	Fulvestrant →	+0.357	+2.649	.038	.046	3	1
BLOOD_Leukemia	PLX-4720 →	-0.403	-2.947	.011	.024	3	1
BLOOD_Leukemia	EPZ004777 →	-0.273	-2.893	.011	.030	3	1
BLOOD_Leukemia	rTRAIL →	-0.341	-2.924	.020	.028	3	1
BLOOD_Leukemia	Sapitinib →	-0.373	-2.964	.005	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

IAP_5620 by HDLBP expression — LARGE_INTESTINE

Explore this box plot interactively →