HDHD5

Across TCGA pan-cancer cohorts, HDHD5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HDHD5 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HDHD5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HDHD5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where HDHD5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.899	0.573	.002	21	view →
CCRCC	OS	Tertile	II,III,IV	0.989	0.133	.020	11	view →
LUAD	OS	Median	III,IV	0.274	0.678	.028	7	view →
PDAC	DFS	Median	II,III,IV	0.295	0.498	.020	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HDHD5–LSCC (OS)

Open the LSCC breakdown →