HDHD5

Across TCGA patient cohorts, HDHD5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDHD5-associated genes across cancer lineages are PKC-a_pS657, PKC-a, and Shc_pY317. Each is linked with HDHD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDHD5-to-partner and partner-to-HDHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by HDHD5-low versus HDHD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDHD5→partner) and Y-score (partner→HDHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-a_pS657 →	+0.400	+2.183	.045	.035	3	1
UCEC	PKC-a →	+0.553	+3.013	.009	.018	3	1
UCEC	Shc_pY317 →	-0.184	-3.000	.020	.036	3	1
UCEC	Caspase-8 →	-0.340	-2.973	.009	.035	3	1
UCEC	cIAP →	+0.168	+3.348	.020	.005	3	1
UCEC	Heregulin →	-0.155	-3.000	.016	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PKC-a_pS657 by HDHD5 expression — UCEC

Explore this box plot interactively →