HDHD5

Across TCGA cell cohorts, HDHD5 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDHD5-associated genes across cancer lineages are ADRA1A, GHRHR, and MOGAT1. Each is linked with HDHD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDHD5-to-partner and partner-to-HDHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by HDHD5-low versus HDHD5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDHD5→partner) and Y-score (partner→HDHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADRA1A →	+0.180	+3.705	<.001	.007	3	2
BLOOD_Leukemia	GHRHR →	+0.337	+3.705	<.001	.007	3	1
BLOOD_Leukemia	MOGAT1 →	+0.025	+4.037	.003	.004	3	1
BLOOD_Leukemia	TEX48 →	+0.032	+4.060	<.001	.003	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
OVARY	GLT6D1 →	+0.409	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ADRA1A by HDHD5 expression — BLOOD_Leukemia

Explore this box plot interactively →