HDHD5

Across TCGA cell cohorts, HDHD5 mutation is significantly associated with the mutation status of many other genes, with 2,297 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDHD5-associated genes across cancer lineages are RIPOR1, RYR3, and AKNA. Each is linked with HDHD5 in more than 3 cancer types. Because this analysis shows association rather than direction, both HDHD5-to-partner and partner-to-HDHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIPOR1 grouped by HDHD5-low versus HDHD5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDHD5→partner) and Y-score (partner→HDHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIPOR1 →	+2.465	+3.156	.005	.005	1	4
BLOOD_Lymphoma	RYR3 →	+2.053	+3.233	.004	.004	1	4
BLOOD_Leukemia	AKNA →	+2.880	+3.495	.002	.002	1	4
BLOOD_Leukemia	PIK3C2B →	+3.787	+4.669	<.001	<.001	1	4
OVARY	CASKIN2 →	+4.415	+4.977	.007	.007	1	4
BLOOD_Lymphoma	VPS13B →	+2.561	+3.157	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,297 associations by consensus.

RIPOR1 by HDHD5 expression — BLOOD_Leukemia

Explore this box plot interactively →