HDHD3

Across TCGA pan-cancer cohorts, HDHD3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HDHD3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HDHD3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HDHD3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where HDHD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.991	0.820	<.001	33	view →
CCRCC	OS	Tertile	All	1.000	0.858	.005	26	view →
GBM	OS	Quartile	All	0.215	0.477	.006	7	view →
LUAD	OS	Median	All	0.661	0.946	.013	2	view →
HNSC	DFS	Median	III,IV	0.875	0.726	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HDHD3–PDAC (OS)

Open the PDAC breakdown →