HDHD2

Across TCGA pan-cancer cohorts, HDHD2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HDHD2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HDHD2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HDHD2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where HDHD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.514	0.248	<.001	49	view →
CCRCC	OS	Quartile	All	0.925	0.725	.010	25	view →
COAD	DFS	Median	II,III,IV	0.879	1.000	.018	24	view →
UCEC	OS	Quartile	II,III,IV	0.308	1.000	.008	14	view →
HNSC	OS	Quartile	II,III,IV	0.921	1.000	.027	6	view →
GBM	OS	Median	All	0.622	0.449	.043	3	view →
LUAD	DFS	Median	II,III,IV	0.742	0.907	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HDHD2–PDAC (DFS)

Open the PDAC breakdown →