HDHD2

Across TCGA patient cohorts, HDHD2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,566 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDHD2-associated genes across cancer lineages are KIF23, RRM2, and KPNA2. Each is linked with HDHD2 in more than 6 cancer types. Because this analysis shows association rather than direction, both HDHD2-to-partner and partner-to-HDHD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDHD2 versus KIF23 in LSCC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDHD2→partner) and Y-score (partner→HDHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF23 →	-0.818	-0.212	<.001	.002	3	7
BRCA	RRM2 →	-1.207	-0.378	<.001	<.001	3	7
BRCA	KPNA2 →	-0.831	-0.330	<.001	.002	3	7
BRCA	AURKA →	-1.173	-0.515	<.001	<.001	3	7
BRCA	CBX7 →	+0.692	+0.347	<.001	<.001	3	6
BRCA	CDKN3 →	-0.954	-0.408	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,566 associations by consensus.

HDHD2 vs KIF23 — LSCC

Explore this scatter interactively →