HDGFL3

Across TCGA patient cohorts, HDGFL3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDGFL3-associated genes across cancer lineages are FOXO3a_pS318_S321, MEK1, and p38-MAPK_pT180_Y182. Each is linked with HDGFL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGFL3-to-partner and partner-to-HDGFL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by HDGFL3-low versus HDGFL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL3→partner) and Y-score (partner→HDGFL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.181	-2.312	.002	.034	3	1
UCEC	MEK1 →	+0.421	+2.459	.017	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.464	-2.446	.033	.020	3	1
UCEC	p62 Lck ligand →	+0.616	+3.594	<.001	.001	3	1
UCEC	PDCD4 →	-0.697	-2.459	.002	.020	3	1
UCEC	Rab25 →	-0.415	-3.000	.009	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FOXO3a_pS318_S321 by HDGFL3 expression — UCEC

Explore this box plot interactively →