HDGFL1

Across TCGA patient cohorts, HDGFL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDGFL1-associated genes across cancer lineages are FOXO3a_pS318_S321, Heregulin, and JNK2. Each is linked with HDGFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGFL1-to-partner and partner-to-HDGFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by HDGFL1-low versus HDGFL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL1→partner) and Y-score (partner→HDGFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.170	-2.321	<.001	.006	3	1
UCEC	Heregulin →	-0.115	-1.807	.024	.027	3	1
UCEC	JNK2 →	+0.245	+3.331	.002	.005	3	1
UCEC	Ku80 →	+0.283	+1.820	.003	.016	3	1
UCEC	MSH2 →	-0.199	-2.973	.036	.035	3	1
UCEC	mTOR_pS2448 →	-0.172	-3.000	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FOXO3a_pS318_S321 by HDGFL1 expression — UCEC

Explore this box plot interactively →