HDGFL1

Across TCGA cell cohorts, HDGFL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 235 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HDGFL1-associated GO terms across cancer lineages are Positive regulation of ubiquitin-dependent protein catabolic process, Isoprenoid metabolic process, and Regulation of ubiquitin-dependent protein catabolic process. Each is linked with HDGFL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDGFL1-to-partner and partner-to-HDGFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ubiquitin-dependent protein catabolic process grouped by HDGFL1-low versus HDGFL1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL1→partner) and Y-score (partner→HDGFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of ubiquitin-dependent protein catabolic process →	+0.068	+0.031	<.001	<.001	3	3
LUNG_SCLC	Isoprenoid metabolic process →	-0.054	-0.017	.004	.008	3	3
LIVER	Regulation of ubiquitin-dependent protein catabolic process →	+0.051	+0.021	.002	.001	3	2
LIVER	Negative regulation of B cell proliferation →	+0.227	+0.023	.007	.001	3	2
LIVER	Regulation of lipopolysaccharide-mediated signaling pathway →	+0.081	+0.019	.008	.003	3	2
LIVER	Positive regulation of synaptic transmission, GABAergic →	-0.173	-0.018	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 235 associations by consensus.

Positive regulation of ubiquitin-dependent protein catabolic process by HDGFL1 expression — LIVER

Explore this box plot interactively →