HDGF

Across TCGA pan-cancer cohorts, HDGF Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HDGF data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HDGF Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDGF expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

SKCM, COAD, and LUSC are the cancer types where HDGF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.023	0.739	<.001	18	view →
COAD	DFS	Median	All	0.189	0.699	<.001	12	view →
LUSC	OS	Median	All	0.264	0.660	.037	9	view →
BLCA	OS	Median	IV	1.000	0.240	.017	8	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HDGF–SKCM (DFS)

Open the SKCM breakdown →