HDGF

Across TCGA pan-cancer cohorts, HDGF mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HDGF data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HDGF mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HDGF expression acts as an unfavorable survival marker, although some lineages such as OV and GBM show a favorable association.

HNSC, OV, and PDAC are the cancer types where HDGF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.605	0.819	.003	62	view →
OV	DFS	Quartile	All	0.835	0.535	.025	8	view →
PDAC	OS	Median	II,III,IV	0.396	0.584	.010	6	view →
LSCC	OS	Tertile	All	0.805	0.927	.017	3	view →
GBM	OS	Quartile	All	0.619	0.320	.003	3	view →
LUAD	OS	Median	All	0.880	0.607	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HDGF–HNSC (OS)

Open the HNSC breakdown →