HDGF

Across TCGA patient cohorts, HDGF mutation is significantly associated with the RNA expression of many other genes, with 888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDGF-associated genes across cancer lineages are OR2D2, TRAJ12, and RN7SKP263. Each is linked with HDGF in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGF-to-partner and partner-to-HDGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D2 grouped by HDGF-low versus HDGF-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGF→partner) and Y-score (partner→HDGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR2D2 →	+0.081	+4.276	<.001	.008	3	2
CESC	TRAJ12 →	+0.558	+4.193	.004	.009	3	2
CESC	RN7SKP263 →	+0.123	+5.569	<.001	.002	3	2
HNSC	METTL7AP1 →	+0.056	+4.655	<.001	.007	3	2
HNSC	MIR3713 →	+0.478	+5.763	<.001	.001	3	2
HNSC	RNU6-87P →	+0.406	+4.221	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 888 associations by consensus.

OR2D2 by HDGF expression — CESC

Explore this box plot interactively →