HDGF

Across TCGA patient cohorts, HDGF mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDGF-associated genes across cancer lineages are ATM, A-Raf_pS299, and Notch1. Each is linked with HDGF in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGF-to-partner and partner-to-HDGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HDGF-low versus HDGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGF→partner) and Y-score (partner→HDGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.567	-2.794	.001	.002	3	2
UCEC	A-Raf_pS299 →	-0.160	-2.222	<.001	.010	3	1
UCEC	Notch1 →	+0.115	+1.584	.037	.036	3	1
UCEC	p62 Lck ligand →	+0.430	+3.916	<.001	<.001	3	1
UCEC	p90 RSK →	+0.199	+2.515	.008	.001	3	1
UCEC	PCNA →	+0.226	+3.459	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by HDGF expression — UCEC

Explore this box plot interactively →