Across TCGA pan-cancer cohorts, HDDC3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HDDC3 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HDDC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HDDC3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where HDDC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.929	0.530	.003	12	view →
LUAD	OS	Median	II,III,IV	0.844	0.330	.006	9	view →
GBM	OS	Tertile	All	0.620	0.418	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HDDC3 tumor-vs-normal RNA expression · all HDDC3 data types