Across TCGA patient cohorts, HDDC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,610 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDDC3-associated proteins across cancer lineages are SLTM, HDLBP, and MPI. Each is linked with HDDC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HDDC3-to-partner and partner-to-HDDC3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDDC3→partner) and Y-score (partner→HDDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLTM →	+0.318	+0.452	<.001	.003	3	5
GBM	HDLBP →	-0.218	-0.274	.006	.003	3	5
OV	MPI →	+0.396	+0.490	.003	.002	3	5
CCRCC	CKAP4_S26 →	-0.895	-0.363	<.001	<.001	3	4
CCRCC	MAP7D1 →	-0.274	-0.259	<.001	.002	3	4
CCRCC	HSPA5 →	-0.293	-0.219	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,610 associations by consensus.

Exploration

HDDC3 survival (RNA) · tumor vs normal (RNA) · all HDDC3 data types