Across TCGA patient cohorts, HDDC3 protein abundance is significantly associated with the RNA expression of many other genes, with 17,397 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HDDC3-associated genes across cancer lineages are YWHAQ, DIAPH3, and KIF2C. Each is linked with HDDC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HDDC3-to-partner and partner-to-HDDC3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDDC3→partner) and Y-score (partner→HDDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	YWHAQ →	-0.619	-0.267	<.001	.002	3	6
BRCA	DIAPH3 →	-1.003	-0.478	<.001	<.001	3	6
BRCA	KIF2C →	-1.000	-0.436	<.001	<.001	3	6
OV	TUBA1C →	-0.777	-0.756	<.001	<.001	3	6
BRCA	BUB1 →	-1.382	-0.463	<.001	<.001	3	6
LSCC	UBXN2A →	-0.515	-0.301	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,397 associations by consensus.

Exploration

HDDC3 survival (RNA) · tumor vs normal (RNA) · all HDDC3 data types