Across TCGA cell cohorts, HDDC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,547 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HDDC3-associated GO terms across cancer lineages are Fructose catabolic process, Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate, and Glyceraldehyde-3-phosphate metabolic process. Each is linked with HDDC3 in more than 11 cancer types. Because this analysis shows association rather than direction, both HDDC3-to-partner and partner-to-HDDC3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDDC3→partner) and Y-score (partner→HDDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Fructose catabolic process →	+0.268	+1.270	<.001	<.001	3	12
OESOPHAGUS	Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate →	+0.268	+1.270	<.001	<.001	3	12
OESOPHAGUS	Glyceraldehyde-3-phosphate metabolic process →	+0.138	+0.790	<.001	<.001	3	9
KIDNEY	Negative regulation of MDA-5 signaling pathway →	+0.128	+0.547	<.001	<.001	3	8
STOMACH	Establishment of epithelial cell apical/basal polarity →	-0.182	-0.957	.001	.001	3	8
LUNG_NSCLC_LUSC	Intracellular transport of virus →	-0.166	-0.808	.003	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,547 associations by consensus.

Exploration

HDDC3 survival (RNA) · tumor vs normal (RNA) · all HDDC3 data types