HDDC2

Across TCGA pan-cancer cohorts, HDDC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HDDC2 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher HDDC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDDC2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

OV, PDAC, and HNSC are the cancer types where HDDC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	0.513	0.876	.017	16	view →
PDAC	DFS	Quartile	All	0.917	0.725	.009	7	view →
HNSC	OS	Median	All	0.992	0.940	.021	7	view →
LUAD	DFS	Quartile	II,III,IV	0.329	0.815	.033	4	view →
CCRCC	OS	Tertile	All	1.000	0.572	.005	3	view →
LSCC	DFS	Median	All	0.703	0.865	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HDDC2–OV (DFS)

Open the OV breakdown →