HDDC2

Across TCGA patient cohorts, HDDC2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDDC2-associated genes across cancer lineages are Sebocytes, Skeletal muscle, and Plasma cells. Each is linked with HDDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDDC2-to-partner and partner-to-HDDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sebocytes grouped by HDDC2-low versus HDDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDDC2→partner) and Y-score (partner→HDDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Sebocytes →	-0.030	-2.967	.039	.036	3	1
UCEC	Skeletal muscle →	+0.081	+3.010	.001	.020	3	1
UCEC	Plasma cells →	-0.027	-2.957	.029	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Sebocytes by HDDC2 expression — UCEC

Explore this box plot interactively →