HDDC2

Across TCGA cell cohorts, HDDC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,030 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDDC2-associated GO terms across cancer lineages are Negative regulation of leukocyte apoptotic process, Ribosomal small subunit export from nucleus, and Glutaminyl-tRNAGln biosynthesis via transamidation. Each is linked with HDDC2 in more than 11 cancer types. Because this analysis shows association rather than direction, both HDDC2-to-partner and partner-to-HDDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of leukocyte apoptotic process grouped by HDDC2-low versus HDDC2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDDC2→partner) and Y-score (partner→HDDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of leukocyte apoptotic process →	-0.139	-1.019	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Ribosomal small subunit export from nucleus →	+0.081	+0.926	.002	<.001	3	11
KIDNEY	Glutaminyl-tRNAGln biosynthesis via transamidation →	+0.106	+0.958	.002	<.001	2	12
PANCREAS	Quinone biosynthetic process →	+0.094	+0.937	<.001	<.001	3	11
PANCREAS	Ubiquinone biosynthetic process →	+0.094	+0.937	<.001	<.001	3	11
LUNG_NSCLC_LUAD	AMP biosynthetic process →	+0.092	+0.754	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,030 associations by consensus.

Negative regulation of leukocyte apoptotic process by HDDC2 expression — PANCREAS

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