HDC

Across TCGA patient cohorts, HDC mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDC-associated genes across cancer lineages are Ku80, JNK_pT183_Y185, and Chk2_pT68. Each is linked with HDC in more than 2 cancer types. Because this analysis shows association rather than direction, both HDC-to-partner and partner-to-HDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by HDC-low versus HDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDC→partner) and Y-score (partner→HDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.275	+1.665	<.001	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.168	-1.379	.002	.019	3	2
LUSC	Chk2_pT68 →	-0.167	-3.160	.005	.019	3	2
LUSC	Cyclin-D1 →	-0.210	-3.124	.013	.019	3	2
UCEC	eIF4E →	+0.144	+2.013	.038	.016	3	2
UCEC	eIF4G →	+0.278	+3.321	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Ku80 by HDC expression — UCEC

Explore this box plot interactively →