HDC

Across TCGA cell cohorts, HDC RNA expression is significantly associated with the go_rna of many other GO terms, with 2,335 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDC-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with HDC in more than 8 cancer types. Because this analysis shows association rather than direction, both HDC-to-partner and partner-to-HDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by HDC-low versus HDC-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDC→partner) and Y-score (partner→HDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of syncytium formation by plasma membrane fusion →	+0.040	+2.068	.002	<.001	3	9
BLOOD_Leukemia	Negative regulation of myoblast fusion →	+0.042	+2.035	.001	<.001	3	8
BLOOD_Leukemia	Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.044	+1.953	.003	.006	3	6
BLOOD_Leukemia	Cytoplasmic translation →	+0.046	+3.637	<.001	<.001	3	6
URINARY_TRACT	Regulation of RNA splicing →	+0.071	+0.094	<.001	.002	3	6
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.076	+0.096	.004	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,335 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by HDC expression — BLOOD_Leukemia

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