HDC

Across TCGA cell cohorts, HDC mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDC-associated genes across cancer lineages are C4orf50, FAM240A, and GLRA2. Each is linked with HDC in more than 1 cancer types. Because this analysis shows association rather than direction, both HDC-to-partner and partner-to-HDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by HDC-low versus HDC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDC→partner) and Y-score (partner→HDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C4orf50 →	+0.237	+2.974	<.001	.008	3	2
LUNG_NSCLC_LUAD	FAM240A →	+0.004	+4.681	<.001	.003	3	2
BLOOD_Leukemia	GLRA2 →	+0.019	+4.054	.002	.004	3	1
BLOOD_Leukemia	IL2 →	+0.611	+4.013	<.001	<.001	3	1
BLOOD_Leukemia	CCKBR →	+0.587	+4.127	<.001	<.001	3	1
BLOOD_Leukemia	C9 →	+0.843	+3.474	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

C4orf50 by HDC expression — BLOOD_Leukemia

Explore this box plot interactively →