Across TCGA pan-cancer cohorts, HDAC9-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HDAC9-AS1 data layer.

The strongest signal is observed in thymoma (THYM), where higher HDAC9-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDAC9-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

THYM, UVM, and CESC are the cancer types where HDAC9-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	All	0.136	0.777	<.001	144	view →
UVM	OS	Tertile	II,III,IV	0.264	0.725	<.001	81	view →
CESC	OS	Tertile	III,IV	0.175	0.765	<.001	72	view →
MESO	DFS	Tertile	II,III,IV	0.091	0.386	<.001	45	view →
KIRC	DFS	Tertile	All	0.345	0.667	.006	42	view →
ESCA	DFS	Quartile	II,III,IV	0.694	0.426	.004	40	view →
PAAD	OS	Tertile	II,III,IV	0.805	0.344	.010	30	view →
LAML	DFS	Quartile	All	0.522	0.741	.010	24	view →
UCEC	DFS	Tertile	III,IV	0.656	0.812	.012	18	view →
BLCA	OS	Tertile	IV	0.187	0.481	.049	9	view →
LIHC	OS	Tertile	III,IV	0.118	0.615	.003	9	view →
THCA	DFS	Tertile	All	0.816	0.902	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

Exploration

Same gene, other analysis: HDAC9-AS1 tumor-vs-normal RNA expression · all HDAC9-AS1 data types