HDAC7

Across TCGA pan-cancer cohorts, HDAC7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HDAC7 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HDAC7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC7 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where HDAC7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.744	0.923	.005	28	view →
LSCC	DFS	Quartile	II,III,IV	0.547	0.939	.018	10	view →
LUAD	OS	Median	III,IV	0.435	0.773	.008	9	view →
CCRCC	OS	Median	All	1.000	0.661	.008	6	view →
GBM	DFS	Quartile	All	0.197	0.502	.002	6	view →
HNSC	OS	Median	All	0.781	0.629	.025	5	view →
OV	DFS	Quartile	All	0.884	0.594	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HDAC7–PDAC (OS)

Open the PDAC breakdown →