HDAC7

Across TCGA patient cohorts, HDAC7 mutation is significantly associated with the RNA expression of many other genes, with 4,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC7-associated genes across cancer lineages are SMIM20, C18orf25, and RAB28. Each is linked with HDAC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC7-to-partner and partner-to-HDAC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM20 grouped by HDAC7-low versus HDAC7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC7→partner) and Y-score (partner→HDAC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SMIM20 →	+0.930	+3.353	.008	.005	3	3
UCEC	C18orf25 →	+0.486	+2.403	<.001	<.001	3	3
UCEC	RAB28 →	+0.416	+3.513	.006	.002	3	3
UCEC	COX11 →	+0.466	+2.413	.001	<.001	3	3
UCEC	MIS12 →	+0.412	+2.392	.006	<.001	3	3
UCEC	NUDCD2 →	+0.500	+3.545	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,153 associations by consensus.

SMIM20 by HDAC7 expression — SKCM

Explore this box plot interactively →