HDAC7

Across TCGA patient cohorts, HDAC7 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC7-associated genes across cancer lineages are eEF2, ACC1, and mTOR_pS2448. Each is linked with HDAC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC7-to-partner and partner-to-HDAC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HDAC7-low versus HDAC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC7→partner) and Y-score (partner→HDAC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.445	+3.459	.001	.005	3	2
UCEC	ACC1 →	+0.438	+2.000	.002	.010	3	2
UCEC	mTOR_pS2448 →	-0.146	-3.308	.012	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.427	-2.321	.015	.034	3	2
UCEC	PCNA →	+0.208	+2.000	.014	.010	3	2
UCEC	PDCD4 →	-0.645	-3.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by HDAC7 expression — UCEC

Explore this box plot interactively →