HDAC7

Across TCGA cell cohorts, HDAC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,255 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDAC7-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Regulation of cell-matrix adhesion, and Hippo signaling. Each is linked with HDAC7 in more than 14 cancer types. Because this analysis shows association rather than direction, both HDAC7-to-partner and partner-to-HDAC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by HDAC7-low versus HDAC7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC7→partner) and Y-score (partner→HDAC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate adhesion →	+0.123	+1.420	<.001	<.001	3	15
BONE	Regulation of cell-matrix adhesion →	+0.145	+1.617	<.001	<.001	3	14
BONE	Hippo signaling →	+0.123	+1.660	.001	<.001	3	14
BONE	Regulation of actin filament organization →	+0.068	+1.356	<.001	<.001	3	14
BONE	Regulation of intracellular transport →	+0.078	+1.136	<.001	.003	3	13
BONE	Negative regulation of Rho protein signal transduction →	+0.155	+1.226	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,255 associations by consensus.

Regulation of cell-substrate adhesion by HDAC7 expression — BONE

Explore this box plot interactively →